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OK K.O.! Let's Be Heroes

2015.11.24 22:28 j-rocc OK K.O.! Let's Be Heroes

A subreddit dedicated to Cartoon Network's OK K.O.! Let's Be Heroes, created by Ian Jones-Quartey.
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2013.05.23 04:01 Pastyourbedtime OK K.O.! Let's Be Heroes

A subreddit dedicated to OK K.O. Let's Be Heros created by Ian Jones-Quartey
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2023.06.09 06:16 CursedHarrenhal A Guide to Jon Snow's friends & foes in the Night's Watch in TWOW (Spoilers Extended)

Hey fellow fans, I've been thinking about Jon Snow and trying to predict what's gonna happen with Jon, Mel, and everyone at Castle Black, as well as the wider Northern narrative. I have some ideas, but one problem that keeps coming up is that we don't know how the brothers of the Night's Watch are going to respond to Jon's murder.
I believe Jon's murder will cause a lot of division in Castle Black; between the NW vs the Wildlings, the NW vs Mel & Selyse... but it will also cause division WITHIN the Night's Watch. Some of the NW seemed to be on Jon's side, while others appear not to be. For the majority of the NW, it's not clear if they support Jon, or hate him, or are indifferent. But I wanna know who's on which side. So here's what I've come up with so far:
JON’S ALLYS
ANTI-JON FACTION
This list only includes NW brothers who are still alive by the end of ADWD. It's hard to say who supports Jon and who doesn't with certainty. So let me give a brief explanation for each of these guys and why I think they will be either pro- or anti-Jon:
PRO-JON FACTION
Horse and Rory fell in beside Jon as he left the Shieldhall. I should talk with Melisandre after I see the queen, he thought. If she could see a raven in a storm, she can find Ramsay Snow for me. Then he heard the shouting … and a roar so loud it seemed to shake the Wall. "That come from Hardin's Tower, m'lord," Horse reported. He might have said more, but the scream cut him off. (Jon XIII, ADWD)
Val, was Jon's first thought. But that was no woman's scream. That is a man in mortal agony. He broke into a run. Horse and Rory raced after him. "Is it wights?" asked Rory. Jon wondered. Could his corpses have escaped their chains? (Jon XIII, ADWD)
Jon saw the flash of naked steel a few yards away. His own bowmen nocked arrows to their strings. He turned in his saddle. "Rory. Quiet them." Rory lifted his great horn to his lips and blew. (Jon V, ADWD)
His friends laughed—Grenn, Toad, Satin, the whole lot of them. (Jon III, ADWD)
Septon Cellador spoke up. "This boy Satin. It's said you mean to make him your steward and squire, in Tollett's place. My lord, the boy's a whore … a … dare I say … a painted catamite from the brothels of Oldtown." And you are a drunk. "What he was in Oldtown is none of our concern. He's quick to learn and very clever. The other recruits started out despising him, but he won them over and made friends of them all. He's fearless in a fight and can even read and write after a fashion. He should be capable of fetching me my meals and saddling my horse, don't you think?" (Jon VIII, ADWD)
Whatever Satin may have done in Oldtown, he is our brother now, and he will be my squire. (Jon VIII, ADWD)
"Is it true that you mean to replace Emmett with this savage Leathers as our master-at-arms? That is an office most oft reserved for knights, or rangers at the least." "Leathers is savage," Jon agreed mildly. "I can attest to that. I've tried him in the practice yard. He's as dangerous with a stone axe as most knights are with castle-forged steel. I grant you, he is not as patient as I'd like, and some of the boys are terrified of him … but that's not all for the bad. One day they'll find themselves in a real fight, and a certain familiarity with terror will serve them well." (Jon VIII, ADWD)
"How many men are enough?" he asked Leathers. "A hundred? Two hundred? Five hundred? A thousand?" (Jon XIII, ADWD)
ANTI-JON FACTION
As for Borroq, Othell Yarwyck claimed the woods north of Stonedoor were full of wild boars. Who was to say the skinchanger would not make his own pig army? (Jon XIII, ADWD)
But others had chosen to absent themselves to show their disapproval. Othell Yarwyck and Bowen Marsh were amongst the missing (Jon X, ADWD)
"I summoned you to make plans for the relief of Hardhome," Jon Snow began. "Thousands of the free folk are gathered there, trapped and starving, and we have had reports of dead things in the wood." To his left he saw Marsh and Yarwyck. (Jon XIII, ADWD)
"These are godless savages," said Septon Cellador. "Even in the south the treachery of wildlings is renowned." (Jon XI, ADWD)
"Who is it?" asked Owen the Oaf. "Not Dywen, is it?" "Nor Garth," said the queen's man she knew as Alf of Runnymudd, one of the first to exchange his seven false gods for the truth of R'hllor. "Garth's too clever for them wildlings." "How many?" Mully asked. "Three," Jon told them. "Black Jack, Hairy Hal, and Garth." Alf of Runnymudd let out a howl loud enough to wake sleepers in the Shadow Tower. "Put him to bed and get some mulled wine into him," Jon told Three-Finger Hobb. (Melisandre I, ADWD)
Othell was surrounded by his builders, whilst Bowen had Wick Whittlestick, Left Hand Lew, and Alf of Runnymudd beside him (Jon XIII, ADWD)
Othell was surrounded by his builders, whilst Bowen had Wick Whittlestick, Left Hand Lew, and Alf of Runnymudd beside him (Jon XIII, ADWD)
"That'd be sweet, m'lord," said Fulk the Flea, "but your wolf's in no mood for company today." Mully agreed. "He tried to take a bite o' me, he did." "Ghost?" Jon was shocked.
CONCLUSION
This list obviously leaves out the majority of the NW, as well as everyone else at Castle Black. Please tell me what you think of my list! I'd like to hear arguments about why should anyone be added or removed from either list?

submitted by CursedHarrenhal to asoiaf [link] [comments]


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2023.06.09 05:58 CassiehunterTX Medusa bala de cañón— Ciudad de Panamá (Jellyfish in Panama City) [pregunta]

Medusa bala de cañón— Ciudad de Panamá (Jellyfish in Panama City) [pregunta]
I am a researcher with STRI (the Smithsonian Tropical Research Institute)— I am here on a brief program to try to sample some Cannonball Jellyfish. I know that this is not the time that they are most common, but if anyone has seen them on beaches or near shore at specific locations, please respond! The goal is to identify whether the Cannonball Jellyfish here and on the Atlantic side is the same. If you have any information at all it will be very useful. Thank you so much, CassieHunterTX
Advertencia: mi español es malo
Soy un investigador de STRI (el Instituto Smithsonian de Investigaciones Tropicales). Estoy aquí en un breve programa para tratar de probar algunas medusas bala de cañón. Sé que este no es el momento en que son más comunes, pero si alguien los ha visto en las playas o cerca de la costa en lugares específicos, ¡por favor responda! El objetivo es identificar si la medusa bala de cañón aquí y en el lado del Atlántico es la misma. Si tienes alguna información será muy útil. Muchas gracias, CassieHunterTX
submitted by CassiehunterTX to Panama [link] [comments]


2023.06.09 05:51 roaminpizza1 Roam’in Pizza Takeaway Redland Bay

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2023.06.09 05:44 MiloJ7 First Session Report

So I finally ran a session with three friends, one had never watched Star Trek and the other two had only watched a few episodes. I ran a homebrewed Kobayashi Maru so that everyone could run it through a few times, trying out different stations and solutions, and getting a feel for the rules of the game. The crew consisted of 3 cadets at Starfleet Academy taking part in a regular training simulation.
Cadet Daksha Ito, Human, pilot.
Cadet Sevek, Vulcan, security.
Cadet V1-803, Hologram, science.
USS Endeavour, NCC-1768-A, simulated Ambassador class starship.
Attempt 1: USS Endeavour on patrol near the Romulan Neutral Zone, Captain V1-803 in command, Sevek at tactical, Daksha Ito at helm. A garbled transmission is received on the emergency band, the crew fails to clear it up but they succeed in determining its origin and set course. They discover an antimatter fuel carrier that seems to have suffered some kind of accident, one of the fuel bunkers has exploded and the ship is drifting into the Neutral Zone. Sensors detected 106 lifeforms aboard, presumably the crew and passengers. Sevek makes a critical success on his attempt to detect any nearby Romulans (helped by his focus Cloaking Detection) and finds a gravimetric anomaly within the Neutral Zone that could be a Romulan ship. Against the wishes of the ship's doctor, who wants to go across immediately, Sevek beams to the Kobayashi Maru with a security team first to secure the ship. Meanwhile V1 and Daksha utilise the Endeavour's tractor beam to pull the Kobayashi Maru away from the Neutral Zone. Sevek secures the bridge, finding a dead pilot but no one else, Dr Washington beams across and, after a failed check by Sevek, she proceeds to head to the passenger deck to treat any injuries, unfortunately the moment she opens the door she takes a blast from a disruptor and is vaporised. The away team beams back under fire and the gravimetric disturbance begins moving out of the Neutral Zone, on course to intercept the Endeavour. Having determined that the gravimetric disturbance was probably a Romulan warbird (It was) the decision was made to fire first, thanks to Sevek's earlier detection of the ship and some critical roles the warbird took the full force of the Endeavour's firepower without its shields. Shortly afterwards a transmission was received from a Romulan fleet lead by the Praetor, he stated that the unprovoked destruction of a Romulan ship would not go unavenged and he declared war on the Federation.
Attempt 2: This one was rather quick. Captain Daksha Ito decided to tow the Kobayashi Maru away from the Neutral Zone and any Romulan vessels by pulling it within the Endeavour's warp field. This time there were no Romulans aboard but there was a risk of antimatter containment breach that the crew would have to deal with. As the crew did not beam aboard or do any kind of remote inspection, the entirety of the Kobayashi Maru's fuel and cargo went up and taking the Endeavour with it. The cadets were left believing that this was the work of Romulan fanatics carrying out a suicide bombing.
Attempt 3: Sevek now in command, Ito at tactical, V1 at helm. This time the crew detects the gravimetric disturbance and successfully makes contact with the Kobayashi Mary, however their attempt to tow the ship suffers a critical failure, the tractoring effect is no evenly distributed and the Kobayashi Maru is cracked in half. Fortunately V1's quick thinking and good rolls managed to save all but 3 of the crew and passengers. The Captain of the Kobayashi Maru has to be talked down from his rage by Captain Sevek before he leads a mob of angry people in a brawl with the Endeavour's crew but fortunately Sevek manages a success on his roll and calms the Captain down, although a report to Starfleet and a demand for reimbursement will be incoming. Unfortunately while the crew was distracted with rescue efforts, the gravimetric disturbance begins moving at high warp towards a nearby Federation colony. The Endeavour moves to intercept at maximum warp and her superior warp drive and some successful engineering rolls allow her to intercept before the ship reaches the colony. The vessel decloaks revealing a Klingon bird of prey with Orion markings painted on her hull. The bird of prey turns to engage the Endeavour nose to nose but misses its attacks, Ito returns fire, scoring critical hits and destroying the bird of prey's engines, the pirate ship is now flying out of control towards the Endeavour. V1 rolls to avoid but fails, the two ships collide and are both destroyed.
It was getting late and mutual destruction seemed a good way to end so I called the session there. The whole thing was a bit janky, with a lot of double checking rules, but everyone had a lot of fun and as first sessions with a new RPG system go I think it was one of my better ones. They're even keen to try out a proper campaign and I've started plotting it out and leading books so that they can create their own characters.
The best part is that is that because they know so little about Star Trek I can tell them that things like "You've been ordered to join a fleet at Wolf 359" and they won't know what's coming.
submitted by MiloJ7 to startrekadventures [link] [comments]


2023.06.09 05:19 geminitwinmom2020 Does this chert look worked or natural? Found in Austin, TX near Onion Creek.

Does this chert look worked or natural? Found in Austin, TX near Onion Creek. submitted by geminitwinmom2020 to Arrowheads [link] [comments]


2023.06.09 05:03 geminitwinmom2020 Found near a remote creek bed in southeast Austin, TX near Onion Creek. Does it look natural or could this be a tool of some sort?

Found near a remote creek bed in southeast Austin, TX near Onion Creek. Does it look natural or could this be a tool of some sort? submitted by geminitwinmom2020 to Arrowheads [link] [comments]


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submitted by Secret-Objective-174 to u/Secret-Objective-174 [link] [comments]


2023.06.09 04:32 short1st [WTS][QC] LCT AK-74U

Up for sale is an LCT TX-S74UN. The name is a mouthful, I know, but it's basically a 74U with a side folder stock and a Picatinny quad rail handguard.
I'm looking for cash mainly, but might consider trading + cash on my end for a pre covid ghk gbbr 74U, ideally with full travel kit. If you have another interesting/good/weird gun to trade, do shoot me a message, no promises though
https://imgur.com/a/GcVERSw
This is a hefty boi, nearly all stamped steel except the rails. It's frankly more dangerous as a blunt weapon than as an airsoft gun.
It comes with a 70 degree Maple Leaf macaron bucking, as well as three LCT midcaps.
Two of them are duct taped together on the photo for fast reloads. I can leave the duct tape on or remove it as you wish.
Asking for $550 obo, slightly negotiable, shipping on buyer
EMT or COD only (buyer pays cod fees)
submitted by short1st to airsoftmarketcanada [link] [comments]


2023.06.09 04:29 Bubzoluck [30 min read] The Opioid Epidemic before the Opioid Epidemic - Exploring Morphine Derivatives and the First Opium War (Part 1)

[30 min read] The Opioid Epidemic before the Opioid Epidemic - Exploring Morphine Derivatives and the First Opium War (Part 1)
Hello and welcome back to SAR! I have written and rewritten this post a few times now and I think I have landed on a format I am happy with. When we talk about the impact of medicine on history its important to get the context right, and I think I have found a way to talk about our topic. So what is it? No chemical is more important to the world of medicine than Opium, okay maybe Penicillin, but today we will say its Opium. Principally an analgesic (anti-pain), the Opium Poppy allowed for humans to take away pain in great degrees and further development on the natural chemicals has opened up surgery and post-op recovery. While we tend to look at the recent Opioid Epidemic as the only issue regarding Opiates, history reveals to us a very similar precursor. Also please head over to u/jtjdp post about morphine derivatives here! She does an amazing job explaining the higher level concepts of medicinal chemistry that I just wouldn’t do justice. Alright, enough quibbling, let’s get to the good stuff.
Disclaimer: this post is not designed to be medical advice. It is merely a look at the chemistry of medications and their general effect on the body. Each person responds differently to therapy. Please talk to your doctor about starting, stopping, or changing medical treatment.

How Much do you Know About Pain?

To be alive is to feel pain, and emo sentiments aside, this is one of the biggest biological properties of the central nervous system. When you think about it, how does the body take external stimuli and allow you to recognize it? The answer is the sensory nervous system which is responsible for sensing many different types of stimuli: temperature, pressure, pain, and chemicals. These sensory neurons carry the information from the extremities and transmit it up the spinal cord into the brain for processing. From there the brain alerts you to the issue allowing you to correct whatever problem is causing the pain. Let’s take a look:

https://preview.redd.it/36yiuubbjw4b1.png?width=660&format=png&auto=webp&s=a8dc870ed6d879d67dce1eb126b86ba5acb9bc69
  • We call these receptors Nociceptors and activation of these neurons in the periphery leads to a signal being sent towards the spinal cord. Those peripheral nerves eventually complex with the Dorsal Horn of the spinal cord and interface with the central nervous system to transfer the pain signal. This signal is then sent Ascending to the Thalamus where the pain signal is recognized and initiates a response (such as pulling your hand away from the hot stove). But that’s not the full story, the brain also sends signals back down Descending to modify the incoming signal and dampen it. Its this modifying that makes pain fade over time when you aren’t focusing on it—otherwise the brain would be overwhelmed by the repetitive signal and continuously think injury is still happening. Now let’s divide this process into its two parts, first up the Ascending pathway.

https://preview.redd.it/w6751owcjw4b1.png?width=896&format=png&auto=webp&s=122f8b2c615f741d848ed0171a574b1353a34038
  • As the Action Potential travels from the periphery towards the Spine it causes the influx of Calcium into the Presynaptic Neuron. This neuron is what carries the original signal to then transfer into the Spine for further traveling. Eventually we reach the Synapse where the finger-nerve and spine meet and we get the transfer of information via Neurotransmitters. In this case, two chemicals are released: Glutamate and Substance P (which literally stands for Substance Pain). Glutamate will activate two receptors (AMPA and NMDA) which are Excitatory and stimulate the continuation of the pain signal up to the brain. Substance P activates the NK1 receptor which enhances the frequency of the pain signal (the throbbing) and the intensity of the pain burst. So to simplify, Glutamate allows the signal to be passed up to the brain but depending on the strength of the original pain signal more or less Substance P is released which modulates the strength and attention-grabbing nature of it. Okay great, we sent the pain pathway up and it will get processed in multiple different parts of the brain. But the brain can’t have that signal stinging it so it must send information back down to dampen that pain signal. This is where that aforementioned Descending pathway comes in. Above you can see how the blue line reaches down out of the brain and back into the spine to turn ‘off’ the signal. This is the basis of Analgesia or pain relief.

https://preview.redd.it/audgj8kfjw4b1.png?width=668&format=png&auto=webp&s=c3b58c520e8298e20f787d70e053948c3817c565
  • Okay so now we have to divide the action of the Descending pathway which acts to dampen and modulate the original signal coming into the brain. Now, normally at rest this Descending neuron is inhibited so any fresh incoming signal is not inhibited from the get go but once that pain signal does come in, we get the good stuff! In response to pain the brain releases substances called Endorphins which activate the mu Opioid Receptor (MOR) located on the Descending pathway. Now MOR are inhibitory in nature so they are inhibiting the inhibitory resting state of neurons, or in other words, are allowing the Descending neuron to activate. And this is an important fact to recognize, Opiates do not inhibit pain, they inhibit the physiology of the nervous system that prevents modulation of the pain signal.
    • Once the inhibition is inhibited, the Descending neuron is free to release two neurotransmitters onto the nerve that was carrying the original pain signal. Both Norepinephrine and Serotonin are released to activate their respective receptors which inhibit the release of Substance P and Glutamate thus decreasing the incoming pain signal. Likewise MOR receptors are found directly on the incoming nerve and further prevent the release of Glutamate and Substance P as well as being found on the Ascending neuron preventing the activation of the NMDA/AMPA and NK1 receptors. The result: dampened incoming signal and decreased pain sense being sent to the brain.

The Stars Align in the Shape of a Poppy


https://preview.redd.it/nfygsi0hjw4b1.png?width=731&format=png&auto=webp&s=60c0b13cdad3d7b7b64f78d6294465f081839f61
To start our story about Opiates we need to turn to the great precursor—Opium. Opium itself is not a chemical but rather a really thick liquor (called latex) that contains a high concentration of Morphine (and some Codeine). There are 38 species of Poppy plants but only two produce Opium is great enough supply that it is worth farming them and humans have been cultivating these varieties for as long as we have known about the plants. When humans settled into Mesopotamia (near modern day Iraq), Poppies were one of the few plants grown in plots as large grain or vegetable fields (meaning that they were thought of as valuable as food). Throughout the Greek age of medicine (pre-500 BCE) through the Islamic medicinal revolution (500 BC-1500 AD), Opium was a major component of treatment, assisted suicide, and poison. In fact its through the rise of the Muslim Caliphates that we see the export of Opium to other parts of the world, especially through the Mediterranean Sea once the Crusaders return. Opium trading to the East via the silk roads was an almost continuous affair since time immemorial and Pakistan was a major growing area for the Eastern Poppy trade.
  • By the time after the Crusades (11-13th centuries), we start to see the West’s fixation on Opium. For many reasons Europe didn’t develop many psychoactive plants to the same degree as more humid/hot climates like Africa, the Middle East, and India. This is why the importation of Opium (and also Marijuana) was such a trade commodity and staple in the development of Western medicine. During the Renaissance and the revival of Greek philosophy we start to see the re-fascination with Opium and by the 1600s we see merchants importing Laudanum into Europe for recreational and medicinal use. The standard use of Tincture of Opium (which is Opium dissolved in ethanol, a DEADLY combination) was a particularly favorite preparation which was prescribed to the lowest day-worker all the way up to kings.
    • The importation and use of Opium exploded in the late 1700s once the British conquered a major Poppy growing region of India. This region (western India and most of Pakistan) was originally slated to grow cotton like the American colonies but the region wasn’t wet enough to sustain the plant—it could however grow copious fields of Poppy plants to create Opium. Throughout the 18th century the British Raj became the largest exporter of Opium to Europe and after the discovery that Mercury and Arsenic may not be safe, Opium took over their duties. By 1780 almost all major remedies incorporated the use of Opium in some capacity and with the huge supply, it was incredibly cheap.

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  • Poppy wasn’t only important to the British for its medicinal properties but also to bolster the huge amount of loss they were incurring in global trade to one trade partner—China. After she made contact with China in the mid-1500s, Britain starting to import HUGE amounts of tea as the Brits became literally addicted to the substance. By 1800 a full 15% of the ENTIRE British Empire’s revenue was being spent on importing tea, that’s 30 million pounds per YEAR, leading to a massive trade deficit. This means that more money was being sent to China literally enriching a foreign country while the British public was getting their fix on the black stuff. Oh and just in case you think things haven’t changed, Britain still accounts for 42.6% of the world’s tea consumption—seriously Brits, ever heard of coffee? Anyways, all this money leaving the British economy to be spent on non-Empire sustaining commodities was a major national security risk for the British. It would be different if they were importing gunpowder like the Dutch were or Silver as the Spanish had but literally they were consuming the riches they were spending the money on.
    • Remember too that the British were not in the best position by the turn of the 19th century—they had just lost their colonies in the Americas, involvement in the Napoleonic Wars killed a generation of men, and the push to develop industries over public health led to a focus on fast growth rather than smart growth. One of the results of the Napoleonic Wars was the British occupation of the Island of Java which developed a very potent Opium which was traded with Chinese merchants regularly. Soon British merchants realized they could rebalance the trade deficit by selling Javanese Opium into China but the small island was unable to produce enough Poppies to meet the demand. So Britain turned to another one of its colonies, India.

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  • India by the end of the 1700s was a bit of a challenge. The British hold on the subcontinent was firm but they couldn’t grow the cash crops they wanted. Indian cotton was nothing compared to Egyptian or Southern American (i.e. Virginia/North Carolina/Georgia) cotton and the Indian tobacco was known for being bitter. But by the 1770s the British government realized that Poppy was an easy crop to grow and the demand across the border with China was an easy market; British traders brought their cargo to small islands off the coast of China where it was sold for silver. Initially the Chinese didn’t mind the sale of Opium in their territory—when the British traders collected the silver from the sale they would almost immediately use it to buy Chinese goods, thus driving tax revenue for the Chinese government.

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  • But if you buy Opium, people are going to use that Opium. By the 1810s all trade with foreigners was restricted to just one port, Canton, and slowly the city started to develop a habit for the drug. The use of mind altering substances was curtailed pretty quickly for hundreds of years in China—the Ming Dynasty banned tobacco in 1640 and the Qing banned Madak (a powdered Opium containing tobacco) was similarly banned in 1729. But by 1790 more and more Chinese citizens were becoming addicted to the substance; what started as a recreational drug slowly became a crippling addiction that took hold over Canton. For a rigid society, the crippling Opiate addiction was a moral corruption for the Qing government and forced them to curtail Opium importation in 1780 and then an outright ban in 1796.

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  • Knowing just how devastating the Opium was having on the inhabitants of Canton, as well as how it spread further inland, British merchants kept peddling their drug. Older ships with larger hulls were converted into floating warehouses and parked just outside of navigable waters. Once set up, Opium smugglers would pull up, purchase the Opium and avoid any oversight by the Chinese government to prevent the sale of the drug. Following their mother country, American merchants started to sell Turkish Opium, an inferior variety, at a much cheaper rate leading to drug peddling competition with more and more tons of Opium being sent into China. This drove down the price of Opium considerably which ultimately increased the demand.
    • This demand eventually led to reversal of trade, meaning that more silver was leaving China to pay for Opium than the British were using to pay for Chinese goods. American and European traders could show up in Canton with holds full of Opium, sell it off for a profit, and then make a tidy silver profit to bring back to Europe. Likewise the importation of cheap machine-made cotton, furs, clocks, and steel into China driving down domestic profits.

Let’s Look at the Drugs a Bit


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Stepping away from the history a bit, let’s introduce the Family. Okay so we understand how pain is sent to the brain and how it modulates but there is so much more to the mu Opioid Receptor and that’s not the only kind of Opioid receptor that we have. The two most clinically useful receptors are the Mu and Kappa Opioid Receptors (KOR) because they result in analgesia but there is a Delta Opioid Receptor (DOR) that is worth mentioning. The majority of the Opiates that we know and love are Mu agonists but there are some very interesting Kappa agonists that are worth mentioning as well.

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  • Above is a chart that shows the binding affinities of select Opiates to the Mu receptor. The smaller the number is, the more tightly they bond. Now affinity is different than potency—potency is a measure of how much drug (in g) is required to produce the same effect. So even though morphine has a higher affinity than fentanyl, fentanyl has a MUCH more potent effect (which is why it can be so dangerous, you only need a little). Now many of the opiates cause the same effect so I want to spend more time on what makes them all so different:
  • First up we have the 5-Ring Morphinians which are derived from the natural product Morphine. These structures have 5 component parts: an aromatic benzene ring (A), a completely saturated bridge ring (B), a partially unsaturated ring with an alcohol attachment (C), a piperidine heterocycle above the rest of the structure (D) and finally a ether linkage between the top and bottom of the structure to keep it fairly rigid (E). Truthfully we are only going to focus on two locations—firstly the top alcohol (red circle) can be methylated to form Codeine, a natural Prodrug of Morphine. A Prodrug is one that is biologically inactive but goes through an initial metabolism once ingested that makes it active.

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  • In fact it’s this initial metabolism of Codeine that makes it very interesting. In order for Codeine to exert any pain relief it needs to be converted to Morphine which actually exerts the desirable properties. This is done by the liver enzyme CYP2D6 which is a pretty minor pathway for Codeine—only about 10% of the Codeine is actually converted to Morphine to have some action. Because of this 2D6 dependent pathway we have to be careful about administering drugs that might inhibit the 2D6 pathway because that would mean we are preventing codeine from being active. Drugs like Fluoxetine (Prozac) and Paroxetine (Paxil) are strong 2D6 inhibitors and so if we administered Codeine to someone taking this drug they’d never get any benefit from the Codeine. In addition there are genetic/ethnic differences that pharmacists can account for such as 2D6 activity. If you are someone with very little 2D6 activity then you would also not convert Codeine to Morphine and thus get no action from the drug—this may be a reason why some people say Codeine doesn’t work for them. Another reason could be that they are Rapid Metabolizers and quickly convert the Codeine to Morphine and thus get a massive hit quickly after ingestion—in that cause you’d need a much smaller dose than another person for the same effect.

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  • A different drug that is the opposite of Codeine is Hydromorphone (Dilaudid) which has a Ketone on ring C. This ketone and the lack of the double bond on this ring increases the lipophilicity of the drug and increases its ability to penetrate into the brain and thus have a greater effect. In fact Hydromorphone is 5-10x more potent than Morphine due to its greater ability to penetrate into the brain and increased receptor affinity for the mu receptor. Because the A ring OH is not capped with a methyl group, we don’t need to rely on 2D6 to metabolize Hydromorphone into an active drug form which again increases the activity of this drug compared to Codeine.
  • So combine these two structural changes—the capped OH on ring A as seen in Codeine and the increased affinity found with the ketone in Hydromorphone and we get Hydrocodone (Norco, Lorcet). Well in this case you’d get a drug that has very good affinity for the mu receptor (better than codeine) BUT is still reliant on the small 2D6 pathway for activation (worse than morphine). In this regard only about 10% of Hydrocodone is active at a time. We can see this effect in the relative doses for equivalent effect: to match the effect of 30mg of Morphine, we’d need only 7.5mg of Hydromorphone (more active) but need 200mg of Codeine (less active).

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  • This brings us to our last drug of this class, Oxycodone which has a special OH group found on Ring B. What you’ll notice is that Oxycodone has that capped OH on ring A so it requires metabolism through 2D6 just like Codeine and Hydrocodone. When it is uncapped it becomes Oxymorphone which has 3 times as much effect as Morphine BUT that extra OH makes Oxycodone an exclusive Mu receptor agonist. Unlike the other drugs which may go to other receptors causing side effects (more on this later).

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  • Next up I want to look at some Mu opioid receptor Antagonists or those than inhibit the function of the opioid receptor. Looking at the first two drugs, Naloxone and Naltrexone, we can see that they have the structure similar to Hydromorphone so they would have incredible brain penetration and affinity for opioid receptors BUT they contain that funky Nitrogen tail. Now normally there is a short methyl tail that is required for the function of Morphine but by adding a bulkier tail the drug is able to fit inside the receptor but prevent activation. What’s most important about these two drugs is that they have much more affinity for the receptor than other opiates. We can see this effect in the graph above: when no Naloxone is present, Fentanyl occupies the opiate receptor about 75% of the time. But as soon as Naloxone is administered that number drops swiftly (within minutes)--this is because Naloxone has a higher affinity for sitting in the receptor than Fentanyl. Think of it like the bully Naloxone coming up and pushing the poor defenseless Fentanyl off the swings so the bully can play on it (except in this instance Fentanyl is causing an overdose and we need to save someone’s life).

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  • Buprenorphine is similar but it is a Partial Agonist instead of being a full antagonist. Buprenorphine is not a 5-ring Morphinian byt a 6-ring Oripavine that has a few different modifications. The biggest additions is that it has the bulky Nitrogen tail found in full Antagonists but it has this funky C ring tail which fights the antagonism. The result is a tug of war between the antagonism of the Nitrogen tail and the agonism of this new C-ring tail resulting in Partial agonism—so if you took Buprenorphine you’d notice a markedly decreased pain relieving ability but importantly there is a ceiling effect, its much harder to overdose on Buprenorphine than other full agonists. In addition in the second graph we can see that Buprenorphine has the greatest affinity for the receptor than our other agonists which prevents someone from taking a more potent opiate while taking Buprenorphine. In this case the bully is already sitting on the swing and scaring away the other kids thus preventing them from having a turn (and potentially causing an overdose). This does mean that if someone was taking a more potent drug (like Fentanyl) and then took Buprenorphine, it would cause withdrawal just like Naloxone or Naltrexone.

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  • Speaking of withdrawal, let’s take a look at how that happens. Remember that the pain signal is caused by the activation of AMPA and NMDA receptors from the peripheral nerve. AMPA is a type of receptor called a G-Protein Coupled Receptor or GPCR which in this case is linked to an Excitatory G-protein which leads to the activation of the nerve. When AMPA is activated, the G-protein (Ga) activates an enzyme called Adenylate Cyclase (AC) which increases the production of pro-activity cAMP—or in simpler terms—when AMPA is activated, it leads to an increase in levels of pro-pain molecule cAMP. The Opioid receptor is also a GPCR but it is linked to an inhibitory G-protein which prevents the action of Adenylate Cyclase and thus leads to a decrease in cAMP levels. So Opiates prevent pro-pain cAMP signaling from continuing.
    • In the second graph we can see how tolerance forms. Initially (A), Adenylate Cyclase and cAMP levels are not affected by having opiates even though their ability to push along the pain signal is blocked. After a few hours, the leftover cAMP is degraded and cAMP levels start to drop significantly (B). In response to these levels going down, the activity of Adenylate Cyclase starts to increase and increase (C) which raises the level of cAMP. This rise in Adenylate Cyclase activity opposes the action of the opiate which necessitates the need for increased doses of Opiates and is why tolerance forms. As sustained inhibition of Adenylate Cyclase continues, the body upregulates Adenylate Cyclase activity to create more cAMP and to combat this we increase the dose.
    • Now what if after years of taking an Opiate we suddenly administer Naloxone, an Opiate antagonist. Well after weeks to months of taking an Opiate, the level of Adenylate Cyclase activity is WAY above baseline. When you administer the antagonist, suddenly Adenylate Cyclase is able to produce a TON of cAMP that normally is blocked which leads to a MASSIVE amount of downstream signaling. The result is intense nausea and vomiting, stomach cramps, fever, anxiety, insomnia, and cravings. Thankfully the withdrawal process ends after about 72 hours but is one of the worst experiences someone can go through which is why proper down-tapering of Opiates is extremely important.

A Change in Trade Policy


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Oh, you’re still here. Neat! So by the 1820s the Qing dynasty was running into many problems regarding Opium. Firstly they needed the Opium taxes to fund their efforts to put down the White Lotus Rebellion and retain power. But after almost 30 years of trade the effects on Chinese communities could not be ignored along with local officials operating under the imperial trade department, the Hong, profiting from bribes to allow Opium. Regardless of initial efforts things were getting out of hand for the Qing government. In 1800, about 4000 chests of Opium or 560,000 pounds entered the country but by 1830 that number exploded to 20,000 chests or about 3 million pounds. But more than the amount of Opium actually entering the country was the incessant rudeness of the British government to open trade.
  • One of the “problems” for the British traders was how clamped down trade was with China. By 1800 all trade was limited to just Canton and the Hong was a strict master of trade. Foreigners were not allowed to appeal decisions made by the Hong and only Chinese traders could sell goods further inland than Canton. Traders chafed against this extreme oversight and sent hundreds of letters to the Hong requesting special dispensations which were summarily denied. Things changed significantly in 1834 when the Chinese trade was de-monopolized away from the East India Company allowing any private trader to get involved in the Eastern trade.

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  • In August of 1834, the British sent Lord William John Napier to Macau as superintendent of Chinese trade with the explicit order to follow all Chinese regulations. Thinking he knows best, Napier decided that the restrictive Chinese trade system was too restrictive and sent a letter to the Viceroy of Canton. This was unheard of—NO foreign traders were allowed to speak directly with Chinese officials and the Viceroy refused to accept it. So why not double down by ordering two British ships to BOMBARD two Pearl River forts as a show of force? Luckily Napier died of Typhus almost directly after else it would have resulted in a full blown war.
  • In 1839 the Qing government appointed Lin Zexu as the Opium czar to completely eradicate the Opium trade from China. Lin banned the sale of Opium in China completely, set up rehabilitation centers for those affected by the drug, and put addicts to work to distract them while detoxing. Lin demanded that all Opium supplies must be surrendered to Qing authorities and any Chinese citizen disobeying the order would be punishable by death. He even went as far as closing the Pearl River Channel, trapping British traders in Canton and seizing their Opium warehouse stockpiles.
  • The replacement for Napier was Admiral Sir Charles Elliot who protested the seizure of the Opium stockpile but knew that they could do nothing. He ordered all Opium ships to flee and prepare for battle which caused Lin Zexu to beseige a group of traders inside a Canton warehouse. Elliot convinced the traders to cooperate with the Chinese government and surrender their stock, saying that the British government would compensate for the lost Opium (which he had no authority to do). During April and May 1839 the British (and American) traders to surrender 20,000 chests of Opium which was burned for three days outside Canton. Following the burning, trade resumed to normal except no more Opium was allowed. Like many other instances of the government removing legitimate sale of a drug, the black market increased markedly.
  • In July 1839 a new scandal rocked the British-Chinese trade system; two British sailors became drunk and beat a man death outside of his village. In response, Superintendent Elliot arrested the two men and paid compensation to the villager’s family for the loss of the man but Elliot refused to hand over the sailors to the Qing government. Lin Zexu saw this as a blatant disregard for Chinese law—afterall traders needed to understand that they can’t just come to China and violate Chinese law as they saw fit. Elliot offered to hold a trial on a British ship in front of Chinese officials to show that the men would not get off free. This incident would start the smoldering.
    • On September 4th, Elliot sent two ships to Kowloon to buy food and provisions from Chinese peasants. While approaching the harbor, three Chinese war junks gave permission to the two British ships to trade but that permission was rescinded by the commander of Kowloon fort. Elliot fumed against the slight and said that if the British were not allowed to trade by 3pm, he would fire on the fort. 3pm passed and the British opened fire on the fort causing the Chinese junks to return fire. The fighting continued for 7 hours until nightfall and Elliot had to prevent the British officers from pressing the attack, thus ending the Battle of Kowloon. Having driven off the Chinese ships, the British purchased the supplies they needed while the Kowloon commander claimed that both ships were sunk and 50 British sailors killed.
    • The reaction in Britain was about as much as you expect. Prime Minister Palmerston sent out letters to the Governor General of India to prepare marines to invade China and another letter to the Chinese Emperor telling him that Britain would send a military force. He sent a letter to Superintendent Elliot to set up a blockade on the Pearl River and capture Chusan Island. He also instructed Elliot to accomplish the following objectives:
      • Demand the respect as a British envoy from the Qing Government.
      • Secure the right for British law to be doled out on British subjects
      • Get recompense for destroyed British property, especially the illegal drugs that they destroyed
      • And most important, End the Canton System thus opening up China to free trade for the first time, ever.
Alright this is where we will leave things off for now, on the brink of war with China. Stay tuned!
submitted by Bubzoluck to SAR_Med_Chem [link] [comments]


2023.06.09 04:20 Fun_Catch8741 SV05 + 4.2.7 + Sprite + CRtouch Klipper

After a few days of work I have managed to get Klipper and Sonic pad working with my Sovol SV05, upgraded to 4.2.7 Creality Mainboard, using Sprite extruder with CR Touch. Below is the config file, if you have anything to add please reply here. Hope it can be of use to someone, as far as I can tell no other config file for this exists on the internet.



#This is a custom Sovol S05 with Creality Sprite hot end config file. #This file contains pin mappings for the Creality "v4.2.7" board. To # use this config, during "make menuconfig" select the STM32F103 with # a "28KiB bootloader" and serial (on USART1 PA10/PA9) communication. # If you prefer a direct serial connection, in "make menuconfig" # select "Enable extra low-level configuration options" and select # serial (on USART3 PB11/PB10), which is broken out on the 10 pin IDC # cable used for the LCD module as follows: # 3: Tx, 4: Rx, 9: GND, 10: VCC # Flash this firmware by copying "out/klipper.bin" to a SD card and # turning on the printer with the card inserted. The firmware # filename must end in ".bin" and must not match the last filename # that was flashed. # See docs/Config_Reference.md for a description of parameters. [display_status] [virtual_sdcard] path: ~/ [gcode_macro START_PRINT] gcode: {% set BED_TEMP = params.BED_TEMPdefault(60)float %} {% set EXTRUDER_TEMP = params.EXTRUDER_TEMPdefault(190)float %} # Start bed heating M140 S{BED_TEMP} # Use absolute coordinates G90 # Reset the G-Code Z offset (adjust Z offset if needed) #SET_GCODE_OFFSET Z=0.0 # Home the printer G28 # Move the nozzle near the bed G1 Z5 F3000 # Move the nozzle very close to the bed G1 Z0.15 F300 # Wait for bed to reach temperature M190 S{BED_TEMP} # Set and wait for nozzle to reach temperature M109 S{EXTRUDER_TEMP} [gcode_macro END_PRINT] gcode: # Turn off bed, extruder, and fan M140 S0 M104 S0 M106 S0 # Move nozzle away from print while retracting G91 G1 X-2 Y-2 E-3 F300 # Raise nozzle by 10mm G1 Z10 F3000 G90 # Disable steppers M84 [stepper_x] step_pin: PB9 dir_pin: PC2 enable_pin: !PC3 microsteps: 16 rotation_distance: 40 endstop_pin: ^PA5 position_endstop: 220 position_max: 220 homing_speed: 50 position_min: -4 [stepper_y] step_pin: PB7 dir_pin: PB8 enable_pin: !PC3 microsteps: 16 rotation_distance: 40 endstop_pin: ^PA6 position_endstop: 220 position_max: 220 homing_speed: 50 position_min: -4 [stepper_z] step_pin: PB5 dir_pin: PB6 enable_pin: !PC3 microsteps: 16 rotation_distance: 8 endstop_pin: probe:z_virtual_endstop position_min: -3.0 position_max: 300 [safe_z_home] home_xy_position: 100, 103 speed: 100 z_hop: 10 z_hop_speed: 20 [extruder] step_pin: PB3 dir_pin: PB4 enable_pin: !PC3 microsteps: 16 gear_ratio: 42:12 rotation_distance: 26.359 nozzle_diameter: 0.400 filament_diameter: 1.750 heater_pin: PA1 sensor_type: EPCOS 100K B57560G104F sensor_pin: PC5 control: pid pid_Kp: 23.561 pid_Ki: 1.208 pid_Kd: 114.859 pressure_advance: 0.0 min_temp: 0 max_temp: 300 [bltouch] sensor_pin: ^PB1 control_pin: PB0 x_offset: -32 y_offset: -39 #z_offset: 0.9 speed: 10 lift_speed: 40 samples: 5 [bed_mesh] probe_count = 4, 4 algorithm = bicubic # probe_count = 5,5 # algorithm = bicubic speed: 100 horizontal_move_z: 5 mesh_min: -12, 1 mesh_max: 173, 171 # # probe_count: 5, 5 # # algorithm: bicubic mesh_pps: 2,2 fade_start: 1 fade_end: 10 fade_target: 0 [bed_screws] screw1: 25,28 screw2: 195,28 screw3: 195,197 screw4: 25,197 [screws_tilt_adjust] screw1: -4,21 screw1_name: front left screw screw2: 155,21 screw2_name: front right screw screw3: 155,190 screw3_name: rear right screw screw4: -4,190 screw4_name: rear left screw horizontal_move_z: 10 speed: 50 screw_thread: CW-M4 [heater_bed] heater_pin: PA2 sensor_type: EPCOS 100K B57560G104F sensor_pin: PC4 min_temp: 0 max_temp: 130 control: pid pid_kp: 64.742 pid_ki: 0.827 pid_kd: 1267.326 [fan] pin: PA0 [mcu] serial: /dev/serial/by-id/usb_serial_1 restart_method: command [printer] kinematics: cartesian max_velocity: 300 max_accel: 1000 max_accel_to_decel: 1000 max_z_velocity: 5 max_z_accel: 100 [board_pins] aliases: EXP1_1=PC6,EXP1_3=PB10,EXP1_5=PB14,EXP1_7=PB12,EXP1_9=, EXP1_2=PB2,EXP1_4=PB11,EXP1_6=PB13,EXP1_8=PB15,EXP1_10=<5V>, PROBE_IN=PB0,PROBE_OUT=PB1,FIL_RUNOUT=PC6 [pause_resume] recover_velocity: 50. # When capture/restore is enabled, the speed at which to return to # the captured position (in mm/s). Default is 50.0 mm/s. [gcode_macro CANCEL_PRINT] description: "Cancel the running print" rename_existing: CANCEL_PRINT_BASE gcode: TURN_OFF_HEATERS M220 S100 ;Reset Speed factor override percentage to default (100%) M221 S100 ;Reset Extrude factor override percentage to default (100%) SAFE_RETRACT SAFE_PARK M106 S0 ;disable fan CANCEL_PRINT_BASE # [mcu rpi] # serial: /tmp/klipper_host_mcu # [adxl345] # cs_pin: rpi:None # spi_speed: 2000000 # spi_bus: spidev2.0 # [resonance_tester] # accel_chip: adxl345 # accel_per_hz: 70 # probe_points: # 150,150,10 #*# <---------------------- SAVE_CONFIG -------------------- #*# DO NOT EDIT THIS BLOCK OR BELOW. The contents are auto-generated. #*# #*# [bltouch] #*# z_offset = 3.001 #*# #*# [input_shaper] #*# shaper_type_x = zv #*# shaper_freq_x = 64.2 #*# shaper_type_y = mzv #*# shaper_freq_y = 73.2 #*# #*# [bed_mesh default] #*# version = 1 #*# points = #*# 0.336500, 0.164500, 0.037500, -0.015500 #*# 0.181500, 0.054000, -0.045500, -0.072000 #*# 0.044000, -0.028500, -0.065500, -0.043500 #*# -0.042000, -0.060500, -0.048000, 0.001500 #*# tension = 0.2 #*# min_x = -12.0 #*# algo = bicubic #*# y_count = 4 #*# mesh_y_pps = 2 #*# min_y = 1.0 #*# x_count = 4 #*# max_y = 170.97 #*# mesh_x_pps = 2 #*# max_x = 172.97

submitted by Fun_Catch8741 to Sovol [link] [comments]


2023.06.09 04:19 CodyWanKenobi46 Any Long-EZ or Cozy mark IV pilots near Long Beach, CA?

I'd love to get a test ride in either or both! Willing to split costs.
I'm starting a build soon and a bit torn between the two. Either way, I'd like to at least sit in one and get a feel for any mods I may want to do with my build. Thank you!
Feel free to reach out here or DM me if you have either of these or know someone that does near Long Beach or the general LA area.
submitted by CodyWanKenobi46 to homebuilt [link] [comments]


2023.06.09 04:02 AutoModerator I HAVE Iman Gadzhi Agency Navigator, Biaheza Dropshipping Course, Andrew Tate all Courses Bundle, And OVER 3,000 MORE COURSES. If ANYONE WANTS them (http://smmacourses.site/)

If ANYONE WANTS them (http://smmacourses.site/)
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· ⭐Sam Ovens - Consulting Accelerator 2023
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· ⭐Montell Gordon - Agency Transmulation
· ⭐Charlie Morgan - Easygrow Course
· ⭐Sebastian Esqueda - Ecom Revolution
· ⭐Biaheza Droppshiping Course 2023
· Andrew Tate – Courses Bundle
· Charlie Morgan - Imperium Agency
· Charlie Morgan - Gym Growth Accelerator
· Biaheza - Full Dropshipping Course 2023
· Jordan Welch - The Reveal 2023
· Savannah Sanchez - TikTok Ads Course 2023
· Iman Gadzhi - Copy Paste Agency
· Sam Ovens - UpLevel Consulting
· Miles – The FBA Roadmap + The Profit Vault
· Andrew Giorgi – Amazon Dropshipping Course
· Sebastian Esqueda – Ecom Revolution Training Program
· Luca Netz – Advanced Dropshipping 2023
· Kevin King – Freedom Ticket 3.0
· Jordan Platten – LearnAds – Facebook Ads Pro 2023
· Miles – The FBA Roadmap + The Profit Vault
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· Top Trade Tools – Top Swing Trader Pro
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· [METHOD] Stop Wasting Money on AI Writers Train And Fine-Tune Your Own AI For Free With No Code ⚡⚡⚡Real Method & Practice Examples ⚡⚡
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· RED CPA FORMULA – UNTAPPED UNDERGROUND CPA SYSTEM
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submitted by AutoModerator to FreeDownload2023 [link] [comments]


2023.06.09 03:48 kodahlyn Ratterys in DFW TX area

Anyone know of any ratterys near the area. I live closer to terrell, TX and most ratterys I've seen are like further west from dfw. Any closer to terrell?. Looked everywhere, really want a breeder instead of pet store! Last ones I got from quinlan, TX but I cannot find the rattery anymore.
submitted by kodahlyn to RATS [link] [comments]


2023.06.09 03:45 AutoModerator Van Tharp – Swing Trading Systems Video Home Study

Van Tharp – Swing Trading Systems Video Home Study
Get the course here: https://bit.ly/Van_Tharp_Swing_Trading_Systems_Video_Home_Study
Van Tharp – Swing Trading Systems Video Home Study

This course has over 10 hours of instruction with significant follow-along documents, which you can download. You can review the videos as many times and as often as you like for two full years.
Swing Trading – A Great Way to Trade:
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  • Are you looking for a series of relatively uncorrelated opportunities to trade nearly every day?
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  • Would you like a more systematic approach to trading?
  • Are you disciplined enough to follow the rules – even though you may not feel entirely comfortable?
  • To trade successfully, do you really know what else you need in addition to HAVING good trading systems?
submitted by AutoModerator to CourseSharingg [link] [comments]


2023.06.09 03:23 Irohsteadcf 26 [M4F] #NYC explore around the city maybe ?

Been a smidge lonely lately and figured Reddit might be able help. Essentially looking to have fun around the city with a cutie. Some type of consistent fwb would be nice. Movie nights , museums, sending shitty memes, going out dancing (can’t dance lol) are up on the menu and more!
I work in LI but live near Manhattan. I like to stay active by lifting or playing basketball. Defiantly consider myself a foodie(Middle eastern, Italian, Spanish food are some of my favorite). I’m traveling to Spain this summer for the first time and can’t wait to stuff my face. Like everyone else I enjoy listening to music and watching shows. Always Sunny, The boys, GoT, better call Saul to name a few. Artist from Van Hallen, Linkin Park, Nas , Fred again, Pink Floyd. Highly open to suggestion cause who doesn’t need new music/shows am I right? I like weed, sneakers, sour candy and game a little too.
I’m 5’9 177lbs athletic build with black hair, brown eyes and a beard.
Ideally I’m looking for someone who is 24+ hwp. Please send a pic I’ll send one back! Tell me about yourself too!
submitted by Irohsteadcf to r4r [link] [comments]


2023.06.09 03:15 Intelligent_Sport_66 Dpe’s near mcallen tx/rgv area or willing to travel?

submitted by Intelligent_Sport_66 to flying [link] [comments]


2023.06.09 03:07 Extension_Carry6844 [CA-BC] [H] QK65 [W] PayPal, local cash

https://imgur.com/a/m0LAkDl
Flawless condition, silver on silver qk65. Comes with aluminum and POM plates, wired hotswap pcb, as well as all the original foams, accessories, and extras. Owlstabs will be included. Selling for upcoming tuition
Looking for 255$ CAD shipped
Currently built on alu with lubed KTT roses (205g0 + 105), TX AP stabs, and PBT caps with plate foam only. Can bundle in for a bit extra
Local to Van Island
submitted by Extension_Carry6844 to mechmarket [link] [comments]


2023.06.09 03:03 Nolia_Dae Please eli5: MRI of the knee results

I’m 35f. I was born with pretty severe in-toeing and my right foot never straightened out completely. I’ve had pain in my right knee as long as I can remember but my biggest issue has always been instability and feeling like it pops out of place. I’ve had many times throughout the last 10 years where I could barely walk on it months at a time. I haven’t always had access to medical care but when I did my insurance denied imaging and sent me to PT, over and over again until I gave up basically. I learned to maneuver myself to avoid pain or instability. But then I fell directly on it in April.
So, I’ve got better insurance now. And (I’m hoping) a orthopedic surgeon & PA who seem to care enough to take a look. And below are the results. My doctors office called me the day after my MRI to book a follow up asap, but asap means July, the day my doctor comes back from vacation.
I’m over here googling every other word and I would really appreciate having a basic understanding of these results. I still plan on seeing my doctor asap! But July feels like forever and a lot of googling I probably shouldn’t do.
Copy/pate, but I deleted the parts that said “grossly intact”
TECHNIQUE: Right knee MRI with 3 imaging planes and 5 imaging sequences on a 3 Tesla MRI scanner. No IV or intra-articular contrast.
FINDINGS: RIGHT KNEE BONES AND CARTILAGES: Moderate to severe tricompartmental osteoarthrosis, severe at lateral compartment with high-grade chondromalacia/near bone-on-bone and probable mild lateral tibial plateau degenerative osseous attrition.
RIGHT KNEE FLUID AND EDEMA: Mild to moderate joint effusion with synovitis. A few tiny subcentimeter loose bodies or foci of nodular synovial thickening at posterior recess of the knee joint. Medium sized complex leaking Baker's cyst.
RIGHT KNEE LIGAMENTS AND TENDONS: Anterior cruciate ligament: Gross intact with periligamentous synovitis Lateral collateral ligamentous complex: Chronic grade 2 sprain and scarring of proximal fibular collateral ligament at lateral femoral condylar attachment and at distal biceps femoris tendon at fibular head insertion. Grossly intact appearing iliotibial band. Medial patellofemoral ligament T medial
RIGHT KNEE MENISCI: Lateral meniscus: Extensive degenerative meniscal tears. Meniscal maceration of anterior horn. Posterior horn meniscal tear near free edge. Peripheral extrusion of macerated anterior meniscal body.
IMPRESSION: 1. Right knee extensive degenerative lateral meniscal tears. 2. Chronic proximal and distal lateral collateral ligamentous sprain and scarring as detailed above. 3. Mild to moderate joint effusion with synovitis and a few tiny subcentimeter loose bodies or foci of nodular synovial thickening. 3. Complex leaking Baker's cyst. 4. Tricompartmental degenerative osteoarthrosis, severe at lateral compartment.
Thank you for your help!
submitted by Nolia_Dae to AskDocs [link] [comments]


2023.06.09 03:02 AutoModerator I HAVE Iman Gadzhi Agency Navigator, Biaheza Dropshipping Course, Andrew Tate all Courses Bundle, And OVER 3,000 MORE COURSES. If ANYONE WANTS them (http://smmacourses.site/)

If ANYONE WANTS them (http://smmacourses.site/)
NEW COURSES (Included when buying my whole collection!):
· ⭐Iman Gadzhi – Agency Navigator 2023
· ⭐Sam Ovens - Consulting Accelerator 2023
· ⭐Cole Gordon – 30 Day Closer
· ⭐Montell Gordon - Agency Transmulation
· ⭐Charlie Morgan - Easygrow Course
· ⭐Sebastian Esqueda - Ecom Revolution
· ⭐Biaheza Droppshiping Course 2023
· Andrew Tate – Courses Bundle
· Charlie Morgan - Imperium Agency
· Charlie Morgan - Gym Growth Accelerator
· Biaheza - Full Dropshipping Course 2023
· Jordan Welch - The Reveal 2023
· Savannah Sanchez - TikTok Ads Course 2023
· Iman Gadzhi - Copy Paste Agency
· Sam Ovens - UpLevel Consulting
· Miles – The FBA Roadmap + The Profit Vault
· Andrew Giorgi – Amazon Dropshipping Course
· Sebastian Esqueda – Ecom Revolution Training Program
· Luca Netz – Advanced Dropshipping 2023
· Kevin King – Freedom Ticket 3.0
· Jordan Platten – LearnAds – Facebook Ads Pro 2023
· Miles – The FBA Roadmap + The Profit Vault
· Dan Vas – Ecom Freedom Shopify Blueprint 2023
· Alexander J.A Cortes - WiFi Money Machine
· Kody Knows - Native Mastery
· Bastiaan Slot - Six Figure Consulting
· Kaibax - Centurion agency
· Joe Robert - Print On Demand Accelerator
· Ryan Hogue - Ryan's Method Dropshipped POD
· Kevin Zhang - Ecommerce Millionaire Mastery
· Ryan Lee – 48 Hour Continuity
· [METHOD] ⚡️TikTok Algorithm Domination Skyrocket your engagement TODAY Updated 2023✨
· Troy Ericson – Email List Management Certification
· Larry Goins – Filthy Riches Home Study Course
· Ry Schwartz – Automated Intimacy
· Patrick Bet-David – All Access Bundle
· Andrea Unger – Master the Code & Go LIVE
· Jon Benson – 10 Minute Sales Letter
· Alen Sultanic – Automatic Clients & Bonuses
· Taylor Welch – Cashflow for Consultants
· Akeem Reed – Slingshot Rental Blueprint
· The Futur Greg Gunn – Illustration for Designers
· Trading180 – Supply And Demand Zone Trading Course
· Jim McKelvey (Foundr) – How To Build An Unbeatable Business
· Master of AI Copy – Copy School by Copyhackers
· Copyhackers – Copy School 2023
· Matei – Gann Master Forex Course
· YOYAO Hsueh – Topical Maps Unlocked
· Tyler McMurray – Facts Verse Youtube Automation Course
· Ashton Shanks – 7 Day Copywriting Challenge Featuring ChatGPT
· Rene Lacad – Rockstar Marketing Blueprint
· Top Trade Tools – Hedge Fund Trender
· Brandi Mowles – Conversion For Clients
· Glen Allsopp – SEO Blueprint 2 (DETAILED)
· Trading Busters – Prop Trading Formula Course
· Sam Woods – The AI Copywriting Workshop (Complete Edition)
· Brian Anderson – Recovery Profit System
· LOW COMPETITION KEYWORDS IN MINUTES ⚡ 70+ REVIEWS ✅ BONUS PDF WORTH $200+
· Devon Brown – Easiest System Ever
· Duston McGroarty – St. Patrick’s Day 2023 Live Event
· Dan Wardrope – Click & Deploy Sales Android
· Lost Boys Academy – How To Make Life Changing Money With OnlyFans!
· WealthFRX Trading Mastery Course 2.0
· TOM & HARRY – Digital Culture Academy
· 100+ Cold Email Templates
· [METHOD] ✅ Make Real Cash with Auto Blogging ⛔Get $1199 Worth of Resources ❌ CUSTOMIZED SECRET PROCESS⚡DONE FOR YOU SITE ⭐ Unlimited Niche Opportunity & So on
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· Raul Gonzalez – Day Trading Institution 2.0
· Rasmus & Christian Mikkelsen –Impact Academy 2023
· [METHOD] ☢️ The Quick eBay Money Loophole Guide ☢️
· Apteros Trading – March 2023 Intensive
· Rob Lennon – Zero to 10k Twitter Accelerator
· Rob Lennon – Next-Level Prompt Engineering with AI
· Rasmus & Christian Mikkelsen – NEW Audiobook Income Academy Download
· Grow and Convert – Customers From Content
· Charles Miller – The Writersonal Branding Playbook
· Kaye Putnam – Convert with a Quiz
· Forex Mentor – London Close Trade 2.0
· Chase Reiner – Fortune Bots Update 1
· Andrew Ethan Zeng – Social Marketing Mastery
· [Method] Upload FULL, 100% Unedited Copyrighted Videos on Youtube! Content ID DESTROYER!
· Digital Daily – Top 150 ChatGPT Prompts to Make your Life Easy
· Patek Fynnip – Psychology Course
· Thomas Frank – Creator’s Companion (Ultimate Brain Edition)
· [METHOD] ⚡ See the MAGIC of Bulk Posting ✨ Untapped Method ✅ [ BONUS ChatGpt and Affiliate list Pdf]✅
· ⭕️ YouTube Content Machine – Unlimited FREE traffic for CPA – Fully Automated Method ⭕️
· Jakob Greenfeld – Scraping The Web For Fun and Profit
· Adrian Twarog – OpenAI Template Starter Kit for ChatGPT / GPT3
· The Secret Merchants List of Over 2000+ Dropshippers and Amazon FBA Suppliers Based in The US
· Top Trade Tools – Top Swing Trader Pro
· Charlie Houpert – Charisma University 2023
· ▶️ [METHOD + GUIDE] ✅ Make Money ✅ with Kindle Books ⚠️ Even if You Can’t Write ⚠️ [STEP-BY-STEP] ⚡ NO INVESTMENT REQUIRED! ⚡
· Charlie Morgan – Easy Grow
· Nina Clapperton – Jasper AI Course for Bloggers
· Travis Stephenson – Simple Profit System
· Manny Khoshbin – Real Estate Starter Program
· Tanner Henkel & Jerrod Harlan – 7-Figure Email Machine
· [METHOD] Stop Wasting Money on AI Writers Train And Fine-Tune Your Own AI For Free With No Code ⚡⚡⚡Real Method & Practice Examples ⚡⚡
· Creator Hooks – YouTube Title Mastery
· Thomas Frank – Creator’s Companion (Ultimate Brain Edition)
· Sean Dollwet – Royalty Hero
· Jason Bell – Birthday Marketing Formula
· NXT Level FX – Investors Domain
· [METHOD] ⏩ My ETSY $40K~ Passive Income 2023 + HOT Products (Earning Proof) ⏪ Make Money No Marketing Easy $40K~ Guide FOR NOOBS ✅
· Rob Jones & Gerry Cramer – Profit Singularity Ultra Edition 2022 (AI & ChatGPT)
· Cody Wittick & Taylor Lagace – The Influencer Marketing Blueprint
· ⚡️➡️$390/Week BLUEPRINT+PROOF✅Scalable Method❤️Amazon to eBay Dropship✅
· Kody Ashmore – Simpler Trading – Drama Free Day Trades ELITE
· Youri van Hofwegen – YouTube Search Automation
· Montell Gordon – Agency Transmutation
· Csaba Borzasi – Breakthrough Conversions Academy
· Tim Denning – Twitter Badassery
· Geoff Cudd – AI Writing Course for Bloggers & Digital Marketers
· RED CPA FORMULA – UNTAPPED UNDERGROUND CPA SYSTEM
· BowtiedCocoon – Zero to $100k: Landing Any Tech Sales Role
· Holly Starks – Make LINK BUILDING Great Again!
· Mike Warren – Deeds4Cash
· BITCOIN BRITS – The Crypto Course
· Max Gilles – ⚡️☄️ UHQ Leak ❤️CPA JACKER – Epic CPA Blueprint✅⚡️
· Aidan Booth & Steve Clayton – 123 Profit Update 9
· Christina Galbato – The Influencer Bootcamp
· John Thornhill – Ambassador Program
· [Sales] 999+ Ultimate ChatGPT Prompts To Copy & Paste (250+ tasks)
· Pollinate Trading – Curvy Trading System
· Content Mavericks – The Greatest Hits Content System
· Andriy Boychuk – Flowium – Klaviyo Mastery 2.0
· Dagobert Renouf – How To Dominate Twitter (Advanced Growth Bundle)
· Darius Lukas – ⭐ The Marketer’s Bible to ChatGPT ✅ 1000+ ChatGPT Prompts to Copy, Paste & Scale
· Billy Gene – 5 Day A.I. Crash Course for Marketers
· Alex Cattoni – Posse Eye Brand Voice Challenge Program
· Casey Zander – YouTube Fame Game Blueprint
· Harlan Kilstein – Midjourney Mastery
· Shawna Newman – YouTube for Niche Sites
· [Marketing] 1099+ Ultimate ChatGPT Marketing Prompts To Copy & Paste (200+ tasks)
· Karen Foo – Star Traders Forex Intermediate Course
· TheMacLyf – Hive Mind & Masterclass (Onlyfans Course)
· Brittany Lewis – Top Seller Secret
· Dan Henry – Facebook Ads for Entrepreneur
· Russ Horn – Ultra Blue Forex
· Scott Phillips – Crypto Salary System
· Roland Frasier – AI Powered Expert Apprentice + Update 1
· Roger & Barry – Give Academy 1k/Day Platinum Mastermind [COMPLETE with LATEST UPDATE]
· Bretty Curry (Smart Marketer) – Smart Amazon Ecommerce
· Steven Dux – Traders Edge 2023
· Aidan Booth & Steve Clayton – 123 Profit
· Allie Bjerk – Tiny Offer Lab
· Dicke Bush – Generate 10x More Content Using AI
· Mateusz Rutkowski – New Money Blueprint
· Smart Raja Concepts (SRC) – Forex 101
· Chase Reiner – Short Form Riches Bootcamp 2023 – AI ChatGPT Bot Update 3
· Chase Reiner – AI Profits
· Travis Sago – Cold Outreach & Prospecting AMA Offer (Best Value with All Bonuses)
· Live Traders – Professional Trading Strategies
· Allan Dib – The 1-Page Marketing Plan Course
· Dan Koe – Digital Economics Masters Degree
· The Trading Guide – The Gold Box Strategy
· The Complete XAUUSD GOLD Forex Scalping System On Real Trading Account
If ANYONE WANTS them (http://smmacourses.site/)
submitted by AutoModerator to FreeDownload2023 [link] [comments]


2023.06.09 02:45 Mass_of_ass Highest Generated Ancient Debris?

Highest Generated Ancient Debris?
Found a Ancient Debris at Y- 113 while digging out a nether hub on a server, loaded a fresh world on the same seed to check if someone had maybe placed it there and its still there.
Seed is -2117725806230029661
Edit: I have ancient debris in my hand so people know what it looks like with my texture pack
submitted by Mass_of_ass to Minecraft [link] [comments]